The trolley tour of Boston, offered as an optional, is the best way to see the entire city. Take it at your own pace, but I would suggest stopping off at the USS Constitution and Fenway.
For ladies I would definitely recommend finding some slightly nicer than normal black flats... I bought some in Prague for super cheap and still wear them all the time!
Make a visit to the Staropramen beer factory, Staropramen is a beer made in Prague and you can tour the factory. It is close by the metro station Andel.